Simulated Moving Bed (SMB) is a versatile technology used for continuous operations such as chromatography, adsorption, ion exchange, and gradient elution. By combining adsorbents with multiple monomers, it achieves high-efficiency, energy-saving, and continuous separation through the “simulated moving” process. The SMB ion exchange system utilizes the carousel principle and valve array control, allowing simultaneous operations such as adsorption, washing, analysis, and regeneration. With one-key start and fully programmed automatic control, the system ensures efficient and seamless operation.
In the SMB system, the columns remain stationary while simultaneously undergoing adsorption, water flushing, elution, and regeneration. Process switching is seamlessly managed through the use of automatic valves, ensuring efficient and continuous operation.
- Impurity removal and decolorization of neomycin sulfate
- Functional sugar processing, such as deliming of erythritol
- Conversion of salts to acids
- Purification of amino acids and other biomolecules
The SMB system optimizes resource efficiency and operational stability through innovative features. Column washing and low-concentration top height reduce water consumption, while on-line backwashing and cross regeneration maintain resin exchange capacity. Column regeneration ensures full utilization of regenerants, minimizing usage amounts. With multiple columns arranged in series and parallel, only one new column is switched at a time, ensuring consistent product quality. The valve array control enables cross-column operations, simplifying equipment maintenance. Additionally, fully automated operation minimizes human intervention, enhancing stability and reliability in product quality.